尿激酶动脉内溶栓治疗急性缺血性脑梗死7例报道

Treatment of Acute Ischemic Stroke with Intra-arterial Thrombolysis Using Urokinase: Seven Case Reports

目的分析尿激酶动脉内溶栓治疗急性缺血性脑梗死的安全性和临床疗效。方法对7例发病在6h内的急性缺血性脑梗死患者用尿激酶行动脉内溶栓治疗,比较溶栓前后的NIHSS评分。结果7例患者经溶栓治疗后血管完全再通;7例患者在14d内神经功能缺损均明显改善;未发生症状性颅内出血及颅外出血并发症。结论我们小样本的研究发现,尿激酶动脉内溶栓治疗急性缺血性脑梗死有一定疗效,但尚需进行大样本随机对照研究证实。

Objective To evaluate the safety and clinical efficacy of intra-arterial thrombolysis using urokinase in patients with acute ischemic stroke. Methods Total 7 patients of acute ischemic stroke in 6h were treated with intra-arterial thrombolysis using urokinase. They were assessed by neurologists using National Institutes of Health Stroke Scale(NIHSS) score at admittance to the hospital, after the treatment and 14d after the treatment. Results Seven patients achieved complete recanalization. It was improved obviously of the neurologic function defect of the 7 patients after 14d. None of cerebral hemorrhage was observed. Conclusion Intra-artery thrombolysis therapy using urokinase for acute ischemic stroke might be safe and effective, but we need a large sample, randomized and control study to confirm.