粒细胞集落刺激因子治疗脑梗死研究进展

Advances in Granulocyte Colony-Stimulating Factor for Cerebral Infarction Treatment

粒细胞集落刺激因子(G-CSF)主要用于各种原因引起的粒细胞减少症。近年来的研究表明G-CSF可用于心肌保护和神经保护等领域。本文主要对G-CSF的由来、结构、来源、信号传导途径及神经保护作用机制进行综述。大鼠脑内存在G-CSF及其受体表达,G-CSF可以减小脑缺血动物模型的梗死灶,促进神经功能恢复,其作用机制可能包括抗炎症、抗凋亡、促进血管生成及神经发生等多种机制。

Granulocyte colony-stimulating factor(G-CSF)is mainly used to treat neutropenia induced by all causes. Recent investigations indicate that G-CSF can be used in cardio-protective and neuroprotective field. This article discusses the G-CSF’s origin, structure, source, signal transducer pathway and neuroprotective mechanism. G-CSF and its receptor are expressed in rat brain. In animal model of cerebral ischemia, G-CSF can reduce infarct volume and improve neural functional recovery. The mechanism of these effects may include anti-inflammatory, anti-apoptosis, enhancing angiogenesis and neurogenesis.