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脑血管储备与阿尔茨海默病 被引量：2

Cerebrovascular Reverse and Alzheimer disease
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摘要 　　阿尔茨海默病(Alzheimer disease,AD)是以进行性记忆和认知功能减退为特点的老年期痴呆.从神经病理学角度看,AD以β淀粉样蛋白(Aβ)在大脑实质和血管壁上聚集,形成淀粉样斑块和淀粉样血管病,并在大脑神经元中形成神经纤维缠结为特征.Aβ由APP(一种跨膜糖蛋白)经一些蛋白水解酶切割而产生[1].脑血管储备(cerebrovascular reserve,CVR)是指在生理和病理刺激调节下,脑血流灌注较基础水平增加的量.……
作者 吕志迈 徐运
机构地区 南京大学医学院附属鼓楼医院神经科
出处 《中国卒中杂志》 2007年第8期679-683,共5页 Chinese Journal of Stroke
关键词 阿尔茨海默病 脑血管储备 诊断
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献40

  • 1[1]Blennow K, de Leon MJ, Zetterberg H. Alzheimer's disease[J]. Lancet,2006, 368:387-403.
  • 2许晶,郑莉莎,张延军.老年期痴呆患者脑血管储备功能的测定[J].中风与神经疾病杂志,2000,17(4):218-220. 被引量：9
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二级参考文献1

  • 1许晶，临床神经病学杂志，1999年，6卷，210页

共引文献8

同被引文献28

  • 1徐运.脑血管储备功能与缺血性卒中[J].中国卒中杂志,2007,2(8):652-654. 被引量：27
  • 2宋秋杰,李林.Alzheimer病神经元凋亡的Aβ级联假说[J].中原医刊,2005,32(7):26-28. 被引量：3
  • 3iadecola C. Neurovascular regulation in the normal brain and in Alzheimer~ disease[ J]. Nat Rev Neuresci ,2004,5:347 -360.
  • 4Shi C, Wu F, Xu J. HzO2 and PAF mediate Abetal -42 -induced Ca2+ dyshomeostasis that is blocked by EGb761 [J]. Neurochem lilt, 2010,56(8) :893 -905.
  • 5Roher AE, Esh C, Kokjohn TA, et al. Circle of Willis atheroscler~r- sis is a risk factor for sporadic Alzheimer~ disease[ J]. Arterioscler Thromb Vasc Biol, 2003,23:1951 - 1953.
  • 6Farkas E, Luiten pG. Cerebral microvascular pathology in aging and Alzheimer~ disease[ J ]. Prog Neurobiol,2001,64 :575 - 611.
  • 7de la Tone JC. Pathophysiology of neuronal energy crisis in Alzheimer ~s disease[ J]. Neurcdegener Dis,2008,5 (3/4) :126 -132.
  • 8Paris D, Humphrey J, Quadros A, et al. Vasoactive effects of A beta in isolated human eerobrovossels and in a transgenic mouse model of Alzheimer~ disease:role of inflammation[ J ]. Neurol Res, 2003, 25:642 -651.
  • 9Christie R, Yamada M, Moskowitz M, et al. Structural and function- al disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy[ J]. Am J Pathol, 2001,158 : 1065 - 1071.
  • 10Kawarabayashi T, Younkin LH, Saido TC, et al. Age dependent changes in brain, CSF, and plasma amyloid - 13 protein in the T~576 transgenic mouse model of Alzheimer~ disease[ J]. J Ncu- rosci, 2001,21:372 -381.

引证文献2

二级引证文献13

中国卒中杂志
2007年 第8期

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