缺血性卒中的神经血管单元保护研究进展

Progress of the Investigations of Neurovascular Unit Protection in Ischemic Stroke

为深入了解局部脑缺血/再灌注的病理生理过程中神经血管单元各个成分的病理反应,本文对相关文献作一综述。神经血管单元是由微血管、神经胶质细胞及其突起、神经元、细胞外基质组成的概念性框架,强调血脑屏障的概念和功能可加深对神经血管单元的理解。缺血/再灌注可损伤神经血管单元的各个成分,在缺血/再灌注的各阶段对神经血管单元的各成分实施多途径的全面保护,可进一步改善缺血性卒中的治疗效果。

The related papers were reviewed for deep comprehension of the pathophysiology of full-scale constituent of neurovascular unit during the focal cerebral ischemia and reperfusion.The neurovascular unit is a concept framework that constitutes of cerebral microvascular endothelium,neuroepithelial cell,neurons,and the extracellular matrix.The comprehension of the concept and function of blood-brain barrier is useful for the understanding of neurovascular unit.All of the components of neurovascular unit will be damaged during the ischemia/reperfusion.The therapy effects of ischemic stroke can be improved if multipath overall protection for neurovascular unit is performed during the different stages of ischemia/reperfusion.