摘要
目的检测caveolin-1在口腔鳞癌中的表达,探讨它与口腔鳞癌的病理分级及临床分期的关系。方法用免疫组化SABC法分析78例口腔鳞癌组织及40例正常口腔黏膜中caveolin-1的表达,并结合临床病理资料作统计分析。结果正常口腔黏膜中caveolin-1表达率为7．50％,口腔鳞癌组织中caveolin-1的阳性率为75．64％,其中Ⅰ、Ⅱ、Ⅲ级阳性率分别为47．62％、79．17％、90．90％,病理分级间比较差别有统计学意义(P<0．05);临床分期0-Ⅳ期阳性率分别为6．67％、30．00％、46．47％、55．56％、75．00％,各期间比较差别有统计学意义(P<0．05)。结论caveolin-1在口腔鳞癌中具有高表达,尤其是在Ⅲ级中。它的表达与病理分级及临床分期有一定的关系,因此,caveolin-1很可能是口腔鳞癌的一种新的肿瘤标志物。
Objective In order to explore the relationship between the expression of caveolin - 1 and pathological grade,clinical stage in oral squamous cell carcinoma,Caveolin- 1 was detected in oral squamous cell carcinoma.Methods Caveolin- 1 expression was detected in 78 cases of oral squamous cell carcinoma and 40 cases of normal oral mucosa using SABC immunohistochemistry.The clinical and pathological data of the patients were collected and used to make statistical analysis. Results The normal oral mucosa had lower caveolin - 1 expression, while the positive of caveolin - 1 expression was 75.64% in oral squamous cell carcinoma.The positive rates of caveolin - 1 expression in the gradeⅠ、Ⅱ、Ⅲof oral squanous cell carcinoma were 47.62%、79.17%、90.90% respectively, which had a significant difference( P < 0.05) .The positive rates of caveolin - 1 expression in stages0、Ⅰ、Ⅱ、Ⅲ、Ⅳ期were 6.67%、30.00%、46.47%、55.56%、75.00%respectively,which had a significant difference( P < 0.05). Conclusion Oral squamous cell carcinoma overexpressed caveolin - 1, caveolin - 1 expression was positively related to the grade and stage of oral squanous cell carcinoma, and caveolin - 1 may be a novel carcinoma biomarker.
出处
《中国实用医药》
2007年第5期8-11,共4页
China Practical Medicine
