刺五加叶皂苷对麻醉犬血流动力学的影响

Effect of acanthopanax senticosus saponins(ASS) on hemodynamics in anesthetized dogs

目的 研究刺五加叶皂苷(ASS)对麻醉犬血流动力学的影响.方法 ASS按7.5、15、30mg/kg给麻醉犬静脉输注60min,应用MF-27型电磁流量计测定外周血流量(PBF)和外周血管阻力(PVR)及其血压(SBP、DBP)和心率(HR)等指标.结果 ASS 15、30mg/kg于给药后30min即能明显增加PBF,同时明显降低PVR,60min达高峰,一直持续到180min,7.5mg/kg对PBF和PVR均无明显影响.此外,ASS 15、30mg/kg于给药后60～180 min可使HR明显减慢,30mg/kg于给药后30～180 min可使SBP及DBP明显降低,15mg/kg有降低SBP及DBP的趋势,7.5mg/kg对HR、SBP及DBP则无明显影响.结论 ASS对心肌缺血的保护作用可能与其明显改善血流动力学有关.

Objective To elucidate the effect of ASS(15and30mg/kg iv drip)on vascular resistance in anesthetized dogs.Methods To measure peripheral blood flow,peripheral vascular resistance,blood pressure and heart rate using the MF-27 electromagnetic flowmeter.Results ASS(15and30mg/kg iv drip)could augmente peripheral blood flow,decrease peripheral vascular resistance within180min and slow down heart rate at 60～180min.In addition,ASS(30mg/kg iv drip)could obviously reduce systolic blood pressure and diastolic blood pressure.Conclusion Protective effect of ASS on my-ocardial ischemia may be by improving hemodynamics.