中老年脑白质疏松症同型半胱氨酸叶酸及维生素B_(12)测定的临床意义

The significance of measuring Homocysteine,folate and Vitamin B_(12) in middle aged and aged patients with leukoaraiosis

目的探讨中老年脑白质疏松症(leukoaraiosis,LA)与同型半胱氨酸(Homocysteine,Hcy)、叶酸及维生素B12的相关性。方法选择CT、MRI证实的中老年LA患者30例,测定其血浆总Hcy、血清叶酸及维生素B12水平,与对照组比较。结果中老年LA患者血浆总Hcy升高,血清叶酸、维生素B12降低,与对照组相比差异有统计学意义(P<0.001),即Hcy水平与中老年LA呈正相关,叶酸、维生素B12水平与中老年LA呈负相关。结论Hcy、叶酸及维生素B12与中老年LA具有相关性,是中老年LA的重要危险因素。

Objective To investigate the relativity of leukoaraiosis in middle aged and aged patients with homocysteine,folate and Vitamin B12.Methods The plasma levels of total homocysteine,serum folate and Vitamin B12 were measured in 30 middle aged and aged cases with leukoaraiosis confirmed by CT and MRI and compared with controls.Results In middle aged and aged patients with leukoaraiosis,the plasma levels of total homocysteine were higher,the levels of serum folate and Vitamin B12 were lower than in the controls.Compared with the controls,the differences had statistic significance(P<0.001).Homoncystine level was positive correlated with leukoaraiosis,whereas folate and Vitamin B12 levels were negatively correlated with leukoaraiosis.Conclusion Correlation existed between leukoaraiosis in middle aged and aged patients and homocysteine,folate and Vitamin B12.Homocysteine folate and Vitamin B12 were important risk factors of leukoaraiosis.