摘要
目的探讨奥沙利铂神经毒性的预防措施。方法入选患者采用FOLFOX化疗方案,随机分为A、B两组。A组为观察组,卡马西平+硫酸镁+钙剂+化疗,在化疗前应用卡马西平100 mg,3次/d口服,连用5 d,硫酸镁1 g化疗前静脉推注,化疗后葡萄糖酸钙1 g静脉推注。B组为对照组,单纯化疗。结果随机对照研究,A组神经毒性发现率为29.4%。B组为61.1%。其中Ⅲ度神经毒性分别为2.9%和5.6%。结论钠离子通道阻滞剂可预防奥沙利铂的急性神经毒性,值得临床进一步探索应用。
Objective To discuss Oxaliplatin nerval toxicity precautionary measure.Methods The patients with FOLFOX chemotherapy divided into group A and group B randomly.Group A was observing group with carbamazepine+magnesium sulphate+calcium agent+chemotherapy,applyed carbamazepine 100 mg before chemotherary three times one day,used five days,applyed magnesium sulphate 1 g before che- motheary,applyed glucobiogen 1 g after chemotherapy.Group B was contrasting group,applyed chemotherapy simply.Results The random contrasting study showed that nerval toxicity finding rate of group A was 29.4%,group B 61.1%.Nerval toxicity 3 degree was 2.9% and 5.6% respectively.Conclusion Sodiumion gap block agent is able to prevent the acute nerval toxicity,Oxaliplatin is worthy for the clinical further exploration and application.
出处
《中国实用医药》
2007年第20期14-15,共2页
China Practical Medicine
关键词
钠离子通道阻滞剂
神经毒性
预防
Sodiumion gap block agent
Nerval toxicity
Precaution
