粤西地区医院278株鲍曼不动杆菌感染调查及耐药情况分析

Analysis of distribution and resistance of 278 strains acinetobacter baumanii in hospital of western Guangdong region

目的了解鲍曼不动杆菌院内感染分布特点、产酶情况和耐药性。方法对278株院内获得性感染鲍曼不动杆菌分布与耐药谱变化进行回顾性分析。结果鲍曼不动杆菌检出率分别为5.73%、6.38%、6.65%和9.21%,标本主要来源于痰(82.37%)。鲍曼不动杆菌感染以重症监护病房(ICU)分布最多(33.09%),大多数菌株对亚胺培南、环丙沙星和氨苄西林/舒巴坦敏感,酶株对大多数β-内酰胺类抗生素基本耐药。结论鲍曼不动杆菌产生β-内酰胺酶是其对β-内酰胺类抗生素耐药的主要原因,鲍曼不动杆菌的感染率和耐药率呈上升趋势,应重视防治。

Objective To investigate the clinical distribution and resistance of Acinetobecter bau- manii.Methods Distribution and resistant patterns of acquired infections of acinetobecter baumanii in hos- pital were analyzed by a retrospective analysis.Results The isolating rate of acinetobacter baumanii were 5.73%,6.38%,6.65% and 9.21%.Sputum specimen counted for 82.37%.Acinetobacter baumanii was mainly distributed in ICU wards.Most acinetobacter baumanii were sensitive to imipenem,ciprofloxacin and ampicillin/sulbactam.β-lactamase producing isolates were resistant to most antibiotics.Conclusion The resistance of acinetobacter baumanii toβ-lactam antibiotics is due toβ-lactamase produced by acineto- bacter baumanii.The infection rate of acinetobacter baumanii is increasing and measures must be adopted for controling Acinetobacter baumanii infection and resistance in hospital.