利培酮治疗精神分裂症的临床验证

An trial of risperidone in the treatment of schizophrenia

目的 验证利培酮治疗精神分裂症的有效性及安全性.方法 对54例精神分裂症住院患者予利培酮1～10 mg/d治疗,疗程为8周.以精神病评定量表评定疗效,以不良反应症状量表评定药物不良反应.结果 治疗结束时显效率(痊愈+显著好转)为64%,有效率88%.利培酮治疗的起效时间为20 d,有效治疗日剂量范围在5.0～6.5 mg.较多见的不良反应为头晕、困倦等.结论 利培酮对精神分裂症的阳性症状及阴性症状均有较好的疗效.

Objective To investigate the safety and efficacy of risperidone in the treatment of schizophrenic patients.Methods A total of 54 cases met to the criteria of diagnosis of schizophrenia were administrated to risperidone for 8 weeks.The dosage of risperidone ranged 1～10 mg/d.The brief psychiatric rating scale(BPRS) was used for the efficacy and Treatment Emergent Sympton Scale(TESS) for unwanted effects.Results Patients were rated as marked improvement(88%).The clinical effectiveness of risperidone showed up at the end of the third week of treatment,and the optimal dose ranged from 5.0-6.5 mg/d.The common side effects of risperidone were dizziness and drowsiness.Conclusion Risperidone is effective in the treatment of positive and negative symptons of schizophrenia.