氯吡格雷应用于急性冠脉综合征疗效分析

Clinical study on the treatment of acute coronary syndrome with clopidogrel

目的观察氯吡格雷应用于急性冠脉综合征的疗效。方法将我院急性冠状动脉综合征(ACS)患者92例随机分为两组,两组均常规使用冠心病二级预防药物,治疗组于以上治疗基础上加用氯吡格雷首剂负荷量300mg,以后75mg,1次/d,随访时间1年,观察两组第1周心绞痛控制情况及1年内心血管事件发生率,进行比较。结果治疗组用药后第1周心绞痛控制情况及1年内心血管事件发生率均优于对照组,差异有统计学意义(P<0.05)。结论氯吡格雷应用于急性冠脉综合征,效果可靠,无明显不良反应,值得临床推广应用。

Objective To investigate the efficacy of clopidogrel on acute coronary syndrome.Methods 92 patients with acute coronary syndrome(ACS)were randomly divided into two groups,both of the two groups were treated with conventional prevention medication for coronary heart disease,the treatment group was initially added clopidogrel loading dose 300 mg and then 75 mg once daily,the follow-up duration was 1 year,the control rate of angina within 1 week and occurrence rate of cardiovascular events within one year were compared.Results The control rate of angina within 1 week was higher and occurrence rate of cardiovascular events within one year was lower in treatment group than in control group,the difference between two groups was significant(P<0.05).Conclusion Clopidogrel is effective and safe for ACS,it deserves the clinical expansion.