赛乐特早期联合黛力新对卒中后抑郁患者的临床观察

The clinical observation of the early combination of seroxat and deanxit in the treatment of post-stroke depression

目的探讨赛乐特早期联合黛力新对卒中后抑郁患者的的临床疗效及安全性。方法将60例卒中后抑郁患者随机分为两组各30例,研究组给予赛乐特联合黛力新治疗,2周后停用黛力新;对照组仅给予赛乐特治疗。疗程均为4周。于治疗前及治疗第1、2、4周末采用汉密尔顿抑郁量表(HAMD)评定临床疗效,药物不良反应量表评定不良反应。结果两组于治疗第4周末HAMD评分较治疗前差异有统计学意义(P<0.01);两组组间比较,治疗第1、2周末两组差异有统计学意义(P<0.05),4周末差异无统计学意义(P>0.05)。两组药物不良反应均较轻,且差异无统计学意义。结论赛乐特早期联合黛力新治疗卒中后抑郁起效快、疗效好,不良反应轻,安全性大,依从性好。

Objective To explore clinical effectiveness and safety of early combination of Seroxat and Deanxit in the treatment of post-stroke depression.Methods 60 patients were randomly divided into two groups,research group(30,treated with the combination of Seroxat and Deanxit for 2 weeks and then treated with Seroxat for 2 weeks)and control group(30,with paroxetine)for four weeks.Clinical effectiveness was assessed with Hamilton Depression Scale(HAMD)and adverse effects with Treatment Emergent Symptom Scale(TESS)before treatment and at the end of lst,2nd,and 4th week after treatment.Results There were more significant difference at the end of 4th week(P<0.01)compared with pre-treatment and significant difference at the end of 1st and 2nd week(P<0.05)between 2 groups.There were little difference at the end of 4th week(P>0.05).Adverse effects of both 2 groups were milder and had no significant difference.Conclusion The early combination of paroxetine and Deanxit in the treatment of post-stroke depression works fast and has better clinical effectiveness,milder adverse effects,higher safety and better compliance.