期刊文献+

老年冠心病患者阿司匹林抵抗的临床观察

下载PDF
导出
摘要 目的探讨老年冠心病患者中阿司匹林抵抗的发生率和临床特点。方法选取就诊前至少1月以上未服用阿司匹林等抗血小板聚集药物的确诊老年冠心病患者50例。检测分别由ADP和AA诱导的PAG等各项指标,然后给予阿司匹100mg/d口服治疗,2周后复查上述各项化验指标,前后对照。根据PAG判定AR,将患者分为阿司匹林抵抗组(AR)和阿司匹林敏感组(AS),对比两组差别。结果50例冠心病患者中有6例由ADP和AA诱导的PAG均高于判定标准,AR发生率为12%。结论通过检测PAG发现,服用阿司匹林的老年冠心病患者中有12%存在阿司匹林抵抗现象。
出处 《中国实用医药》 2007年第31期92-93,共2页 China Practical Medicine
  • 相关文献

参考文献9

  • 1[1]Antiplatelet Trialist's Collaboration.Collaborative overview of randomized trial of antiplatelet therapy2 Ⅰ:Prevention of death,myocardial infarction,and stroke by prolonged antiplatelet therapy in various categories of patients.BMJ,1994,308:81-106.
  • 2[2]Antiplatelet Triallist's Collaboration.Collaborative overview of randomized trial of antiplatelet therapy2 Ⅱ.Maintenance of vascular graft or arterial patency by antiplatelet therapy.BMJ,1994,308:159-168.
  • 3[3]Antiplatelet Trialist's Collaboration Collaborative overview of randomized trial of antiplatelet therapy2 Ⅲ.Reduction in venous thrombosis and pulmonary en2 bolism by antiplatelet prophylaxis among surgical and medical patients.BMJ,1994,308:235-246.
  • 4[4]Eikelboom JW,Hirs HJ,Weitz JI,et al.Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction,stroke or cardiovascular death in patients at high risk for cardiovascular events.Circulation,2002,105 (14):1650-1655.
  • 5[5]Gum PA,Kottke-Marchant K,Poggio ED,et al.Profile and Prevalence of Aspirin Resistance in Patients With Cardiovascular Disease.Am J Cardiol,2001,88 (3):230-235.
  • 6[6]Helgason CM,Bolion KM,Hoff JA,et al.Development of aapiri resistance in persons with previous ischemi stroke.Stroke,1994,25:2331.
  • 7[7]Weber AA,Zimmermann KC,Meyer2Kirchrat h J,et al.Cyclooxygenase22 in human platelet s as a possible factor in aspirin resistance.Lancet,1999,353 (9156):900.
  • 8[8]Vane JR,Bakhle YS,Botting RM.Cyclooxygenases 1 and 2.Ann Rev Pharmacol Toxicol,1998,38 (1):97-120.
  • 9[9]Macchi L,Christiaens L,Brabant S,et al.Resistance to aspirin in vitro is associated wit h increaaed platelet sensitivity to adenosine diphosphate.Thromb RES,2002,107 (122):45-49.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部