胰胆管合流异常之胆囊炎患者胆囊黏膜增殖性变化

Proliferation changes of gallbladder mucosa in cholecystitis patients with pancreaticobiliary maljunction

目的观察合并胰胆管合流异常之胆囊炎患者胆囊黏膜增殖性的变化。方法对照观察4年间胰胆管合流异常与胰胆管汇合部正常之成人胆囊炎患者中的胆囊黏膜增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)染色切片,比较两者间增殖性的差异。结果4年内通过术中胆道造影及内镜逆行胰胆管造影检查检出17例胆囊炎合并胰胆管合流异常患者,其增殖细胞核抗原阳性率为(32.05±5.17)%;而另17例经检查明确胰胆管汇合部正常之成人胆囊炎患者则为(24.16±6.33)%;精确卡方检验显示两组间胆囊黏膜增殖性差异有统计学意义(P<0.01)。结论胆囊炎患者胆囊黏膜增殖性在合并胰胆管合流异常者高于胰胆管汇合部正常者。

Objective To investigate the proliferation changes of gallbladder mucosa in cholecystitis patients with pancreaticobiliary maljunction. Methods To identify the pancreaticobiliary maljunction patients from adults with cholecystitis by endoscopic retrograde cholangiopancreatography and by intraoperative cholangiography in 4 years; to compare the proliferating cell nuclear antigen positive rates of gallbladder mucosa with those adults patients of normal pancreaticobiliary junction. Results There were 17 cholecystitis patients with pancreaticobiliary maljunction picked out by endoscopic retrograde cholangiopancreatography and by intraoperative cholangiography during last 4 years, in which the proliferating cell nuclear antigen positive rates of gallbladder mucosa were (32.05±5.17)%; when it went to comparison group, the proliferating cell nuclear antigen positive rates were (24.16±6.33)%. The differences of proliferating cell nuclear antigen positive rates between two groups above were statistically significant(P<0.01). Conclusion The gallbladder mucosa proliferation of cholecystitis patients with pancreaticobiliary maljunction is higher than that of patients with normal pancreaticobiliary junction.