期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

rhG-CSF对大鼠局灶性脑缺血认知功能的保护作用

The preventive effects of rhG-CSF on cognition function after focal cerebral ischemia in rats
下载PDF
导出
摘要 目的观察重组人粒细胞集落刺激刺激因子(rhG-CSF)对大鼠局灶性脑缺血后空间记忆的脑保护作用。方法采用光化学法制作大鼠局灶性脑缺血模型,用Morris水迷宫检测大鼠空间记忆能力。结果大鼠局灶性脑缺血后大鼠空间记忆能力降低,rhG-CSF能提高大鼠局灶性脑缺血后大鼠空间记忆能力,rhG-CSF对大鼠局灶性脑缺血后神经元有保护作用。结论大鼠局灶性脑缺血损害大鼠空间记忆能力,rhG-CSF对大鼠局灶性脑缺血后空间记忆能力有保护作用。 Objective To investigate the preventive effects of rhG-CSF on cognition function after focal cerebral ischemia in rats.Methods Focal cerebral ischemia was induced by Photochemically Initiated Thrombosis.Cognition function was test by the Morris Water Maze.Results It was found that the cognition function decreased after focal cerebral ischemia in rats,rhG-CSF could increased cognition function after focal cerebral ischemia in rats.rhG-CSF have preventive effects on cognition function after focal cerebral ischemia in rats.Conclusion Focal cerebral ischemia can damage the rats' spatial memory and the rhG-CSF can alleviate this damage.
作者 张敬军 陈青 赵敬富 梁颜涛 张金冉 刘平
机构地区 山东省泰山医学院 泰安卫校
出处 《中国现代药物应用》 2007年第10期4-6,共3页 Chinese Journal of Modern Drug Application
基金 山东省卫生系统高层次人才1020工程资助项目
关键词 脑缺血 重组人粒细胞集落刺激因子 MORRIS水迷宫 认知功能 Cerebral ischemia rhG-CSF Morris Water Maze Cognition function
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献11

  • 1[1]Liao FL,Peng J,Li W.Microthrombogenesis induced by rose bengal under ordinary microscopic illumination.World congress for Microcirculation,1996,119 (2):479-482.
  • 2[2]Watson BD,Prado R,Veloso A,et al.Cerebral blood flow restoration and reperfusion injury after ultraviolet laser-facilitated middle cerebral artery recanalization in rat thrombotic stroke.Stroke,2002,33 (2):428 -834.
  • 3[3]Watson BD,Dietrich WD,Busto R,et al.An improved photochemical model of embolic cerebral infarction in rats.Stroke,1997,22:22-25.
  • 4[4]Kocher AA,Schuster MD,Szabolcs ML,et al.Neovascularization of ischemic myocardium by human bone marrow derived angioblasts cardiomyocyte apoptosis reduces remodeling and improves cardiac function.Nat Med,2001,7(4):430-436.
  • 5[5]Gibson CL,Bath PM,Murphy SP.G-CSF reduces infarct volume and improves functional outcome after transient focal cerebral ischemia in mice.J Cereb Blood Flow Metab,2005,25(4):431-439.
  • 6[6]Hu B,Yasui K.Effects of colony stimulating factors(CSFs) on neutrophil apoptosis:possible roles at inflammation site.Int J Hematol,1997,(2):179-188.
  • 7[7]Zhang ZG,Zhang L,Jiang Q,et al.Bone marrow derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse.Circ Res,2002,90:284-288.
  • 8[8]Ji JF,He BP,Dheen ST,et al.Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury.Stem Cells,2004,22:415-427.
  • 9[9]Chen Jl,Li Y,Lei WL,et al.Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats.Stroke,2001,32:1005-1008.
  • 10[10]Watson BD,Dietrich WD,Busto R,et al.Induction of reproducible brain infarction by photo-chemically induced thrombosis.Ann Neural,1985,17(5):497-504.
中国现代药物应用
2007年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部