中医药治疗肺癌研究思路和临床经验

Research Thought and Clinical Experience in Treatment of Lung Cancer with Chinese Medicine

在中医理论的指导下,对肺癌的病因病机、辨证分型、治疗原则进行的研究认为,肺癌主要是由于正气虚损,痰气瘀毒胶结于肺部而成,临床以阴虚内热、气阴两虚、脾虚痰湿、阴阳两虚及气滞血瘀等5个证型为主。对以滋阴生津法、益气温阳法、益气养阴法为主等不同治法治疗肺癌的临床疗效进行了系统观察总结,结果表明中医药治疗肺癌不仅能改善症状,提高患者免疫功能与生活质量,而且具有病灶稳定率较高,生存期较长的特点,并显示其在抗转移方面具有潜在的优势。针对肺癌以阴虚和气阴两虚证患者为多数的临床特点,研制具有益气养阴解毒功效的中药制剂益肺抗瘤饮,临床随机分组治疗非小细胞肺癌。益肺抗瘤饮组及化疗加益肺抗瘤饮组治疗后肿瘤缩小稳定率、5年生存率和中位生存期均优于单纯化疗对照组,显示益肺抗瘤饮治疗气阴两虚型非小细胞肺癌具有良好的疗效,与化疗合用有明显的增效作用。

Guided by theories of Chinese medicine,the causes,pathogenesis,syndrome differentiation and classification,and therapeutic principles of lung cancer were studied,which showed lung cancer was mainly caused by deficiency of healthy qi,cementation of phlegm and qi as well as toxin in lung.Five categories were established according to clinic manifestations:yin deficiency and internal heat,deficiency of qi and yin,spleen deficiency and phlegm dampness,deficiency of yin and yang,qi stagnation and blood stasis.Clinic effectiveness of different therapeutic methods,such as nourishing yin and promoting body fluid,supporting qi and warming yang,supporting qi and nourishing yin were systematically observed,showing Chinese medical therapy can not only relieve symptoms and improve immunity functions and life quality of the patients,but also better stabilize focus of cancer,and prolong survival time,moreover,it has potential advantages in anti-metastases.As deficiency of yin and deficiency of both qi and yin were mostly seen in clinic,Chinese materia medica preparation of Yifei Kangliu drink was prepared,which had function of supporting qi,nourishing yin and detoxicating.We treated patients with non-small cell lung cancer(NSCLC) by Yifei Kangliu drink and Yifei Kangliu drink plus chemotherapy as well as chemotherapy individually,and compared them in terms of tumor shrinking stability rate,five-year survival rate and median survival rate.The results suggested Yifei Kangliu drink had good effect on NSCLC,and Yifei Kangliu drink plus chemotherapy had even better effect.