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喘咳宁方治疗发作期哮喘的实验研究

Empirical Study of Kechuanning in Treatment of Asthma at Period of Onset
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摘要 目的探讨中药咳喘宁方在治疗哮喘中的作用和可能的机制,为治疗哮喘提供依据。方法将60只小鼠随机分为6组,除正常对照组外,其余各组小鼠均于实验第1、7、14日腹腔注射0.2mg/ml抗原液,并于第14日超声雾化吸入0.05%卵蛋白,连续14日。正常对照组每日予生理盐水。地塞米松对照组、低、中、高剂量咳喘宁组分别以0.0617mg/ml地塞米松、98.7mg/ml、197.4mg/ml、394.8mg/ml咳喘宁治疗。采用免疫组化染色法,比较各组BALF中TGF-β水平。结果发作期哮喘小鼠BALF中TGF-β水平较正常对照组显著升高。结论咳喘宁方治疗发作期哮喘的可能机制是抑制TGF-β的产生。 Objective:To explore functions and possible mechanism of a Chinese medical prescription-Kechuanning and provide evidences for treatment of asthma. Methods: 60 mice were randomly divided into 6 groups, all of which were given 0.2mg/ml antigen solution at 1, 7, 14 day, except for the normal control group, then inhaled 0.05% egg albumin by ultrasonic atomization for 14 consecutive days. The normal control group was given sodium chloride everyday. Treatment groups were treated respectively with 0.0617mg/ml Corson, 98.7mg/ml、197.4mg/ml、394.8mg/ml Kechuanning. Immuno-histrochemical staining method was used to compare levels of TGF-β in BALF. Results: level of TGF-β in BALF rose remarkably as compared to that of the normal control group. Conclusion: The result suggested that Kechuanning's performed its functions through inhibition of production of TGF-β.
作者 蒋可 罗侃
出处 《世界中医药》 CAS 2007年第3期172-173,共2页 World Chinese Medicine
关键词 哮喘/中医药疗法 @咳喘宁 Asthma at period of onset/ Chinese medical therapy @ Kechuanning
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参考文献2

  • 1[2]Kips JC,Pauwels RA.Airway wall Remodeling:does it occur and what does it mean Clin Exp Allergy,1999,29(11):1457~1466.
  • 2[3]Hauttori A,et al.FEBS Lett,1994,340:177~180.

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