摘要
The activity and enantiocontrol ability of the chiral catalysts prepared from spiro di-phosphine ligands, SDP, and rhodium precursor were investigated in the asymmetric catalytic Pau-son-Khand reaction. The results showed that SDP ligands were very effective in Rh-catalyzed Pau-son-Khand reaction, and their complexes with rhodium could convert a variety of 1,6-enyne compounds into bicyclopentone derivatives under CO atmosphere in high yields with good enantioselec-tivities. The SbF6- was found to be a suitable counter anion of the catalyst, and 1,2-dichloroethane was the best choice of the solvent for Pauson-Khand reaction.
The activity and enantiocontrol ability of the chiral catalysts prepared from spiro di-phosphine ligands, SDP, and rhodium precursor were investigated in the asymmetric catalytic Pau-son-Khand reaction. The results showed that SDP ligands were very effective in Rh-catalyzed Pau-son-Khand reaction, and their complexes with rhodium could convert a variety of 1,6-enyne compounds into bicyclopentone derivatives under CO atmosphere in high yields with good enantioselec-tivities. The SbF6- was found to be a suitable counter anion of the catalyst, and 1,2-dichloroethane was the best choice of the solvent for Pauson-Khand reaction.
作者
FAN Baomin1, LI Shen2, XIE Jianhua2, WANG, Lixin2, TU Yongqiang1 & ZHOU Qilin2 1. State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000,China
2. State Key Laboratory of Elemento-organic Chemistry,Nankai University,Tianjin 300071, China
基金
This work was supported by the National Natural Science Foundation of China (Grant Nos. 20132010 and 20272026)
the Major State Basic Research Development Program (Grant No. G2000077506)
the Ministry of Education of China and the Committee of Science and Technology of Tianjin City for financial support.
