血府逐瘀口服液治疗冠心病心绞痛临床观察

Clinical Observation on Effect of Xuefuzhuyu Oral Solution on Coronary Heart Disease with Angina Pectoris

目的观察血府逐瘀口服液治疗冠心病心绞痛的临床疗效。方法选择冠心病心绞痛患者80例,随机单盲分为两组,血府逐瘀口服液组和西药对照组各40例,分别予以血府逐瘀口服液和西药消心痛、阿司匹林对照治疗四周。结果血府逐瘀口服液组、西药对照组总有效率分别为92.5%和75%;心电图疗效,血府逐瘀口服液组、西药对照组有效率分别为66%和40%,两组比较差异均有显著性(P﹤0.05);血府逐瘀口服液组治疗后血胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)明显降低(P﹤0.05,P﹤0.01),西药对照组LDL-C则有所升高(P﹤0.05)。结论血府逐瘀口服液对冠心病心绞痛在改善心绞痛症状、缺血心电图改变等方面有较好疗效,同时还可降低TC及LDL-C,降低动脉硬化指数。

Objective To observe the effect of Xuefuzhuyu Oral Solution(XFOS) in treating coronary heart disease with angina pectoris. Methods Eighty patients were randomly divided into two groups. They were treated with XFOS group and isosorbide dinitrate combined aspirin(control group) respectively for 4 weeks and observed by single blind method. Results The total effective rate in relieving angina in the XFOS group and the control group was 92.5% and 75% respectively , that in improving ECG changes was 65% and 40% respectively, the difference of the two parameters between the two groups was significant, all P<0.05.Levels of total cholesterol(TC) and low density lipoprotein-cholesterol(LDL-C)were lowered in the XFOS group while LDL-C was increased in the control group. Conclusion XLOS has better effect in improving angina pectoris, ischemic changes in ECG, it could also reduce the serum TC and LDL-C level and decrease the arteriosclerosis index.