艾司洛尔对全麻插管时心血管反应的临床观察

Effect of Esmolol on inhibiting Cardiovascular Stress by General Tracheal Intubation

目的研究艾司洛尔预防由气管插管引起的血液动力学变化。方法80例全麻病人随机分为两组,A组为应用艾司洛尔组2.0mg/Kg,B组为对照组。静注咪唑安定、丙泊酚、芬太尼和维库溴铵诱导,气管内插管。监测给药前、插管前及插管后1、3、5及10min心率(HR)、收缩压(SBP)、舒张压(DBP)。结果B组在插管过程中HR明显增快,与A组比较有显著差异(P<0.05)。A组SP、DP插管过程中有短时间轻度增高,B组增高明显且持续时间较长,两组比较有显著差异(P<0.01)。结论艾司洛尔在诱导前应用可有效缓解气管插管时的心血管反应。

Objective To investigate the effects of esmolol in inhibiting cardiovascular stress during general tracheal intubation.Methods 80 patients scheduled for general anesthesia were randomly divided into two groups.Group A use esmolol in dosage of 2.0mg/kg.Group B as control group.Introduction by Midazolam,Propfol,Fentanyl and Norcuron and tracheal intubation was performed.Monitoring HR,SP,DP at time point before esmolol induction,tracheal intubation and 1min,3min,5min,10min after tracheal intubation.Results HR of group B increased obviously.There was significant difference between B and A(P<0.05).SBP and DBP of group B has a slightly and short increasing.Group B was increased obviously and the time was longer and significant difference exist(p<0.01).Conclusion Esmolol can attenuate effectively the cardiovascular stress by general tracheal intubation.