再生障碍性贫血患者心脏结构和功能变化研究

The Study of heart structure and function changes in patients with aplastic anemia

目的寻找再障患者心脏结构和功能变化的规律,提出再障合并心肌病的诊断标准。方法对53例再障患者的临床特征,X线,心电图及超声心动结果分析,并将患者按病程长短及贫血程度分为4组观察,Ia组为病程1年下,Hb<60g/L;I为病程1年以下,Hb>60g/L;IIa组为病程1年上,Hb<60g/L;IIb组为病程1年以上,Hb>60g/L。结果53例患者中42例超声心动结果出现心脏结构不同程度的改变,但心电图及X线结果大多正常。其中5例心脏明显扩大(LVEDD>60mm),功能改变,EF<50%,见于Ia、IIa、IIb中。心电图T波异常见于IIa中。结论再障患者的心脏结构及功能的改变与病程的长短及贫血的程度有关,超声心动检查对其诊断价值最大。

Objective The purpose of the study was to evaluate the changes of heart structure and function in aplastic anemia (AA), and determine the diagnostic criterion of AA cardiomyopathy.Methods 53 AA were studied. Their clinical features, X-ray, ECG and UCG were analysised . According to the courses of disease and Hb, they were divided into four groups. When the course of the disease shorter than 1 years, the patients were classified as group I. according to the Hb, they were classified into group Ia Hb <60g/L, and group Ib Hb>60g/L. Group II were the patient's course longer than 1 years. Group IIa were Hb<60g/L, group IIb were Hb>60g/L.Results The heart structure abnormal were found in 42 patients, but the results of ECG and X-ray were normal. In group Ia,IIa and IIb, 5 patients have the enlarge left ventricular, LVEDD>60mm, EF<50%. In group IIa, T-wave abnormal can occur.Conclusion The changes of heart structure and function in AA were correlated with the course of disease and anemia. The UCG were important in diagnosis of AA cardiomyopathy.