辛伐他汀对蛛网膜下腔出血患者ET、NO浓度的影响及临床意义

Effects of simvastatin on levels of CSF and serum ET and NO for patients with subarachnoid hemohrrage

目的研究辛伐他汀对蛛网膜下腔出血患者脑脊液、血清ET、NO水平的影响,探索其疗效机制。方法86例患者被分层随机分配到3组,在基础治疗的基础上给10mg,20mg辛伐他汀或不服辛伐他汀,1周、2周时测定脑脊液、血清中ET、NO浓度。结果1周后辛伐他汀组脑脊液、血清NO浓度较对照组明显高;辛伐他汀组脑脊液、血清ET浓度较对照组明显降低;2周时两辛伐他汀组水平也有显著性差异:20mg辛伐他汀组脑脊液、血清NO浓度较10mg辛伐他汀组明显高,而脑脊液、血清ET浓度较10mg辛伐他汀组明显降低。结论辛伐他汀可增加蛛网膜下腔出血患者脑脊液、血清NO水平,降低脑脊液、血清ET浓度而改善临床症状。

Objectives To study the effects of simvastatin on levels of CSF and serum ET and NO for patients with subarachnoid hemohrrage, and explore mechanisms of it's efficacy. Methods 86 cases were randomly stratified into 10mg simvastatin group,20mg simvastatin group and control group. Levels of ET and NO were determined at 7th and 14th day. Results At 7th day, CSF and serum NO levels for simvastatin groups were significantly higher than control group, CSF and serum ET levels for simvastatin groups were significantly lower than control group; CSF and serum NO levels for 20mg simvastatin group were significantly higher than 10mg simvastatin group, CSF and serum ET levels for 20mg simvastatin group were significantly lower than 10mg simvastatin group at 14th day . Conclusions simvastatin can increase CSF and serum NO level and decrease CSF and serum ET level for SAH patients and improve clinical symptoms.