急性百草枯中毒患者体液免疫功能的变化及意义

目的探讨急性百草枯中毒患者体液免疫功能的变化及意义。方法采用速率散射比浊法检测47例急性百草枯中毒患者及30例正常人血清IgG、IgA、IgM、C3、C4水平,并作了动态观测。结果急性百草枯中毒患者血清中毒后24～72hIgG、IgA、IgM、C3、C4均升高,中毒后第7日存活组仍高于对照组,而病死组血清IgA、C3、C4则显著低于正常(P<0.01或P<0.01)。结论急性百草枯中毒患者体液免疫功能早期增强,随着病程进展极危重者免疫功能出现抑制。

Objective To explore the change of humoral immune function in patients with acute Paraquat poisoning(APP) and its significance. Methods Serum IgG? IgA?IgM?C3?C4 levels were measured using rate scatter nephelometry in 47 patients with APP and 30 cases of normal subjects; at the same time the dynamic observation was made. Results Serum IgG IgA IgM C3 and C4 level in 47 APP were higher than that of 30 normal subjects at 24 hous or 72 hous(P<0.05 or P<0.01). that of survival patients were yet higher than those of normal controls respetively at seventh day after poisoning.but those of deadly patients ware decreased at seventh day after poisoning. IgA?C3 and C4 of deadly patients were remarkably lower than those in controls(P<0.05 or P<0.01).Conclusions The humoral immune function is enhancement in APP patients at early stage. Immunosup- pression may exist in patients with severe poisoning in the late stage.