顺铂、5-氟脲嘧啶联合吉西他滨治疗晚期鼻咽癌的初步研究报告

The clinical report of the patients of advanced nasopharyngeal carcinoma treated with gemcitabine plus cisplatin and 5-FU

目的了解国产吉西他滨(泽菲)联合顺铂、5-FU方案治疗晚期鼻咽癌的疗效和毒副作用。方法自2002年10月～2005年1月,32例晚期鼻咽癌病人入组,对32例晚期鼻咽癌予以吉西他滨1000mg/m2静滴,第1、8天;顺铂30mg/m2静滴,第1～3天;5-Fu500mg/(m2·d)静脉滴注d1～5,每3周为1个周期,连用4周期。方案治疗结束4周后观察评价疗效、毒副反应。结果全组可评价病例30例,其中CR2例,PR14例,总有效率53.3%,中位生存期为11.2月。主要毒副反应为骨髓抑制和胃肠反应、脱发,绝大部分病人均能耐受。结论国产吉西他滨(泽菲)联合顺铂、5-FU化疗方案治疗局部鼻咽癌有效。

Objective To study the efficacy and adverse effect of patients of advanced nasopharyngeal carcinoma treated with Gemcitabine plus Cisplatin and 5-FU. Methods From October 2002 to January 2005, thirty-two patients of advanced nasopharyngeal carcinoma were randomized into our group: Gemcitabine 1 000mg/m2 intravenous infusion d1?8; Cisplatin 30mg/m2,intravenous infusion, d1～3, 5-FU 500 mg/m2 intravenous infusion, d1～5. The two regimens were repeated every two weeks and totally four to six cycles. The evaluation is performed four weeks after the completion of chemotherapy. Results Thirty patients had evaluable lesions.For the experimental group: the RR rate is 53.3%, The main toxicity is myelosuppression,alopecia and GI discomfort. But it could be well tolerated by most patients. Conclusions Gemcitabine plus Cisplatin and 5-FU is effective to patients of advanced nasopharyngeal carcinoma.