宫颈癌患者的凝血象研究

目的探讨凝血象在宫颈癌患者中的变化。方法分别采用全自动血细胞分析仪及凝血仪对宫颈癌患者凝血象包括血小板(PLT)、血小板平均体积(MPV)、血小板比积(PCT)和血小板体积分布宽度(PDW)以及凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶时间(TT)和D-二聚体(D-D)予以检测。结果与正常对照组、子宫肌瘤组比较,宫颈癌患者PLT、PCT、FIB和D-二聚体显著增高(p<0.01);MPV显著降低(p<0.01);而PDW、PT-INR、PT、APTT和TT无显著性差异(p>0.05)。结论宫颈癌患者凝血功能增强,抗凝及纤溶活性降低,机体处于高凝状态,有血栓形成的倾向。

Objective To study hemocoagulation in patients with cervical carcinoma. Methods Plateles(PLT) plateletcrit(PCT)mean platelets volume (MPV) platelet volume distribution width (PDW) Prothrombin time(PT)activated partial thromboplastin time (APTT)fibrinogen(FIB)thrombin time (TT) and D-dimer (D-D) were determined in patient with cervical carcinoma. Results PLTPCTFIB and D-D in patient with cervical carcinoma were significantly increased compared to control group and uterine leiomyoma group(p<0.01). MPV was significantly decreased (p<0.01) and there was no change of PDWPT-INRPTAPTT and TT(p>0.05). Conclusions The state of activation of coagulation and fibrinolysis should be existed in patients with cervical carcinoma.