摘要
目的观察大剂量转换酶抑制剂(ACEI)及受体拮抗剂(ARB)联合治疗糖尿病肾病综合征的疗效并评价其安全性。方法采用随机对照法将51例糖尿病肾病综合征患者分为对照组和治疗组,观察用常规剂量与加用大剂量ACEI及ARB联合治疗的疗效差异,治疗前后监测24小时尿蛋白(UP)、血肌酐(Scr)、血浆白蛋白(ALB)及血脂状况,并进行对照。结果治疗组在提高疗效、降低Scr、减少UP、增加ALB及改善血脂状态方面与对照组相比均有明显统计学意义,且无严重不良反应发生。结论在糖尿病肾病综合征常规治疗基础上,加用大剂量ACEI及ARB联合治疗能明显促进各项指标好转、提高疗效、安全性好、可进一步改善糖尿病肾病综合征的临床预后。
objective To investigate the efficacy and satety of large-dose ACEI and ARB on diabetic nephritic syndrome. Methods 51 patients with diabetic nephritic syndrome were randomly divided into large-dose ACEI and ARB treated group and control group . patients in control group received routine therapy ,While those in treatment group were treated with routine therapy large-dose ACEI and ARB. A series of experimehtal markers were observed before and 8 weeks after the trial. Results After treatment all parameters were improved in both groups There were significant difference in all parameters between treatment and control groups.Conclusions Large-dose ACEI and ARB, With its safety and reliabitity,has been proved clinical benefits to meliorate prognosis in treatment of patients with diabetic nephritic syndrome
出处
《中国医药导报》
CAS
2006年第29期39-40,共2页
China Medical Herald
关键词
糖尿病肾病
转换酶抑制剂
受体拮抗剂
疗效
Diabitic nephritic syndrome
ACE inhibitor
AⅡ recaptor blocker
Efficacy