尿微量蛋白在高血压患者早期肾损害中的作用

The role of Urinary micro protein in hypertensive patients of the earlier renal damage

目的探讨老年高血压病患者早期肾损伤和尿微量蛋白的变化。方法对150例老年高血压患者和65例正常对照者,进行血压、尿微量白蛋白(ALB)、尿视黄醇结合蛋白(RBP)、尿免疫球蛋白(IgG)、血肌苷、尿素氮、总胆固醇、甘油三酯和空腹血糖各项指标观察。结果高血压病患者ALB、RBP、IgG和尿素氮显著升高(P<0.01)。多因素Logistic回归分析发现,收缩压和肌苷是ALB的独立危险因子(P<0.01,P<0.05);收缩压和舒张压是RBP的独立危险因子(P<0.01,P<0.05);收缩压是IgG的独立危险因子(P<0.01)。结论高血压病患者ALB、RBP、IgG和尿素氮显著升高,而其中的收缩压是ALB、RBP、IgG的独立危险因子,因此收缩压在早期肾损伤具有更重要的作用。

Objective Study the changes of renal function and urine microprotein in old hypertensive patients.Methods We have observed blood pressure, retinal binding protein(RBP), IgG, Microalbuminuria(ALB), blood inosine, urea nitrogen, total plasma cholesterol, plasma triglyceride and fasting blood sugar in 150 cases older hypertension patients and 65 cases normal control patients. Results The levels of ALB, RBP, IgG and urea nitrogen were significantly increased in the older hypertension patients(P<0.01). With stepwise multivariate logistic regression analysis, systolic blood pressure and blood inosine were identified as significant and independent risk factors for ALB (P<0.05, P<0.01), systolic blood pressure and diastolic blood pressure were identified as significant and independent risk factors for RBP(P<0. 05, P<0.01), systolic blood pressure was identified as significant and independent risk factors for IgG(P<0. 01). Conclusions ALB, RBP, IgG and urea nitrogen were significantly increased in the older hypertension patients. And the systolic blood pressure is the independent risk factors for ALB, RBP, IgG. The systolic blood pressure may play an important role in the earlier renal damage.