阿齐霉素与克林霉素交替治疗儿童支原体肺炎的疗效观察

Observation of Azithromycin followed by Clindamycin in The treatment of Pediatric Mycoplasma Pneumonia

目的:探讨阿奇霉素、克林霉素交替治疗儿童支原体肺炎的疗效。方法:对确诊的支原体肺炎患儿进行随机分组,单用阿奇霉素组予静滴阿奇霉素针剂,1次1d,10mg1kg1d,疗程为3d;单用克林霉素组予盐酸克林霉素40mg1kg1d,分2次静脉滴注,疗程为7d;阿奇霉素、克林霉素交替治疗组第1d～3d予静滴阿奇霉素针剂,1次1d,10mg1kg1d,第4d～7d予盐酸克林霉素40mg1kg1d,分2次静脉滴注。结果:单用阿奇霉素组与阿奇霉素、克林霉素交替治疗组疗效比较及单用克林霉素组与阿奇霉素、克林霉素交替治疗组疗效比较,均有显著性差异(p<0.05);克林霉素副反应发生率低于阿齐霉素(p<0.05)。结论:阿奇霉素、克林霉素交替应用治疗支原体肺炎,疗效优于单用阿奇霉素或克林霉素。

Objective:To investigate the effect of Azithromycin followed by Clindamycin in the treatment of pediatricmycoplasma pneumonia.Methods: Patients with mycoplasma pneumonia were randomized divided into group A( Azithromycinthreated group, n=15) , group B( Clindamycin threated group, n=15) and group C( Azithromycin followed by Clindamycin threatedgroup, n=15) .In group A Azithromycin were given intravenously with the dosage of 10mg1kg1d for 3 days.In group B Clindamycinwere given intravenously with the dosage of 40mg1kg1d for 7 days.In group C Azithromycin were given intravenously with thedosage of 10mg1kg1d for 3 days, followed by Clindamycin giving intravenously with the dosage of 40mg1kg1d for 4 days.Results:The responsive rate of group C was significantly higher than that of group A or group B.The adverse reaction incidence ofClindamycin was lower than that of Azithromycin.Conclusion: The protocol of Azithromycin followed by Clindamycin gets betterresponsive to mycoplasma pneumonia in children compared to that of Azithromycin or Clindamycin.