盐酸左旋咪唑经鼻腔给药治疗小鼠变应性鼻炎的药效学研究

Researches on pharmacological effects of levamisole hydrochloride in mouses with allergic rhinitis

目的:考察盐酸左旋咪唑经鼻腔给药治疗小鼠变应性鼻炎的疗效,为治疗变应性鼻炎寻找新的药物。方法:建立小鼠变应性鼻炎的模型,以布地奈德为阳性对照药,以生理盐水为阴性对照药,经鼻腔给予盐酸左旋咪唑后,观察变应性鼻炎小鼠鼻粘膜的水肿、嗜酸性粒细胞浸润IL-12的表达情况。结果:阳性对照药物雷诺考特与盐酸左旋咪唑都能改善组织水肿、显著抑制嗜酸细胞的浸润并有效地提高组织中IL-12的生成表达;但布地奈德抑制嗜酸细胞效果比盐酸左旋咪唑好,而其促IL-12表达不如盐酸左旋咪唑。结论:盐酸左旋咪唑经鼻腔给药可能对变应性鼻炎具有一定的治疗效果,其机理与布地奈德不一样,有可能成为新的变应性鼻炎的治疗药。

Objective:To assess pharmacological effects of levamisole hydrochloride administered per nasal cavity in mouses with allergic rhinitis.Methods:To set up allergic rhinitis model in mouses,levamisole hydrochloride was administered per nasal cavity.Rhinocort as positive control and physiologic saline as negative control were administered by the same route as levamisole hydrochloride.After administration of drugs,pathological indexes in nasal mucosa such as oedema,infiltration of eosinophil and IL-12 expression were assessed.Results:Both of levamisole hydrochloride and positive control rhinocort could relieve oedema,inhibit infiltration of eosinophil and improve IL-12 expression.But rinocort was more effective in inhibiting infiltration of eosinophilic cells and less effective in improving IL-12 expression than levamisole hydrochloride.Conclusion:Levamisole hydrochloride is effective to allergic rhinitis in mousse by a different mechanism to rhinocort,it is a potential therapeutic drug for allergic rhinitis.