脑梗死患者急性期血清C反应蛋白的动态变化及临床意义

Dynamic Changes and Clinical Significance of Serum C-reactive Protein in Patients with Acute Cerebral Infarction

目的探讨急性脑梗死(ACI)患者血清C反应蛋白(CRP)的含量变化及其临床意义。方法随机选择80例急性脑梗死患者,采用液相免疫沉淀散射比浊法对患者检测血清CRP水平,按梗死灶大小分组观察,并对其神经功能缺损进行标准评分。结果急性脑梗死不同梗死灶组比较,大小梗死组卒中后5～7d水平最高,随后逐渐下降,两组均较腔梗组为高(P<0.01);不同临床分型组间比较,重型组明显高于中型、轻型组、(均P<0.01)。结论血清CRP水平增高与急性脑梗死发生、梗死灶大小和严重程度关系密切、CRP可考虑作为急性脑梗死患者评估病情的指标之一。

Objective To investigate dynamic changes and clinical significance of serum C-reactive protein (CRP) concentrations in the patients with acute cerebral infarction(ACI). Methods The levels of serum CRP in 60 patients with acute cerebral infraction were measured by liquid phase immunoprecipitation scatter immunoturbidimetry. The serum CRP levels of different groups which were divided by the size of cerebral infarction focus weredetected. The neurologie impairment degree was evaluated. Results The blood levels of serum CRP were the highest on the first 5 -7 days in the acute cerebral infarction groups, then gradually decreased. CRP levels of these two groups were also higher than those of the lacuna group(P<0.01 ). As compared with the medium group or the mild group, the serum concentration of CRP was markedly higher in severe patients (P<0.01). Conclusion The serum levels of CRP are closely connected with the occurrence of ACI, as well as the size of cerebral infarction focus and the severe degree. It can be one of the sensitive markers for evaluating the patient's condition and prognosis of ACI.