奥扎格雷钠治疗进展性脑卒中疗效观察

The Observation Therapeutic Effect of Sodium Ozagrel in Treatment of Progressive Ischemic Stroke

目的探讨奥扎格雷钠治疗进展性脑卒中的疗效与安全性。方法将90例进展性脑卒中患者随机分为两组,治疗组45例患者应用奥扎格雷钠注射液80 mg溶于0．9%氯化钠溶液250 ml中静滴,早晚各1次,同时加用低分子右旋糖酐500 ml,川芎嗪80 mg,1次/d静滴,连用14 d;对照组45例患者应用低分子右旋糖酐500 ml,川芎嗪80 mg,1次/d静滴,连用14 d。两组患者同时应用低分子肝素钠5000U皮下注射,2次/d,连用7 d。观察两组患者治疗前后神经功能缺损评分,血小板聚集率等指标的变化。结果两组患者疗效间差别有显著性意义(P＜0．05);治疗后两组患者的全血黏度、纤维蛋白原水平、血小板聚集率间差别均有显著性意义(P＜0．05);两组患者的不良反应经对症处理后消失,差别无显著性意义。结论奥扎格雷钠治疗进展性卒脑中安全有效。

Objective To evaluate the therapeutic effect of sodium ozagrel in treatment of progressive ischemic stroke. Methods 90 cases of progressive ischemic stroke patients were allocated randomly into two groups:treatment group and control group(45 cases in every group).The treatment group was given 5000U LMWH subcutaneously twice a day;80 of sodium oza- grel,Dextran 40 500ml,80 of Ligustrazine intravenously once a day.The changes of the neurological deficit scores and platelet aggregation rate were observed in both groups before and after 14d treatment.Results The defference of total effective rate and platelet aggregation rate in the treatment group was significant compared to the control group(P＜0.05).Conclusion Sodium ozagrel is effective and safety in treatment of progressive ischemic stroke.