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基质金属蛋白酶-9与脑缺血

Matrix Metalloproteinase -9 and Ischemic Cerebrovascular Diseases
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摘要 脑缺血后基质金属蛋白酶-9(MMP-9)因其表达细胞众多、作用底物广泛而备受医学界重视。脑缺血后表达的MMP-9能降解基底膜而破坏血脑屏障,导致血管源性脑水肿和出血性转化。MMP-9抑制剂有可能成为治疗脑血管病的一条新途径。 Because of the multitudinous cell express and general substrates in ischemic cerebrovaseular diseases,MMP - 9 is highly emphasized.After cerebral ischemia,MMP - 9 can degrade the basal lamina and disrupt the blood - brain barrier so lead to vasogenic brain edema and hemorrhagic transformation.MMP -9 inhibitor may become a new approach in treatment of ischemic cerebrovascular diseases.
作者 郭晓斌 吴成翰
机构地区 福建中医学院 福建中医学院附属第二人民医院
出处 《中国卒中杂志》 2006年第11期817-820,共4页 Chinese Journal of Stroke
关键词 基质金属蛋白酶-9 脑缺血 血-脑脊液屏障 Matrix metalloproteinase-9 Ischemic cerebrovascular diseases Blood-brain barrier
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献26

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中国卒中杂志
2006年 第11期

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