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血管炎患者血清SDF-1α水平变化及临床意义 被引量：1

Serum SDF-1α level in patients with vasculitides and its clinical significiance
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摘要 目的检测结缔组织病患者血清中SDF-1α水平,探讨其在血管炎中的水平变化与患者其他实验室检测指标的关系。方法选取血管炎患者28例,系统性红斑狼疮合并雷诺现象和混合结缔组织病合并雷诺现象病患者14例,系统性红斑狼疮不合并雷诺现象的患者20例,采用ELISA方法检测该3组患者及20例正常对照者血清中SDF-1α的水平。结果血管炎患者血清SDF-1α水平为(3495.12±1099.39)pg/mL,系统性红斑狼疮合并雷诺现象和混合结缔组织病合并雷诺现象病患者血清SDF-1α水平为(7207.46±4011.11)pg/mL,系统性红斑狼疮不伴雷诺现象的患者SDF-1α水平为(6 546.97±2 897.71)pg/mL,均明显高于正常对照组水平((2 124.43±438.11)pg/mL,P<0.01),且患者血清SDF-1α水平与ESR、AN-CA、尿α1微球蛋白具有明显正相关。结论血管炎患者的SDF-1α水平明显升高,且与ESR、ANCA、尿α1微球蛋白存在明显正相关,提示SDF-1α在血管炎的发病过程中具有重要作用。 Objective To investigate the relationship between the serum SDF-1α level and other laboratory indexes in patients with vasculitides and explore the role of SDF-1α in vasculitides.Methods The level of SDF-1α from 28 vasculitides patients,14 systemic lupus erythmatosus(SLE) with Raynaud's phenomenon and mixed connective tissues disease(MCTD) with Raynaud's phenomenon,20 SLE without Raynaud's phenomenon,and 20 healthy individuals were detected by enzyme linked immunosorbent assay(ELISA) respectively.Results Th...
作者 冯璐 王晓非 蒋莉 张晓莉 郭韵 陈涓涓 李舒帆
机构地区 中国医科大学附属第一医院风湿免疫科 中国医科大学
出处 《免疫学杂志》 CAS CSCD 北大核心 2009年第4期428-430,共3页 Immunological Journal
关键词 血管炎 结缔组织病 雷诺现象 SDF-1Α vasculitides connective tissue disease Raynaud's phenomenon SDF-1α
分类号 R593.9 [医药卫生—内科学]
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免疫学杂志
2009年 第4期

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