Th17研究进展

Research progress of T helper 17

人们传统上将CD4+辅助性T细胞分成两个主要的亚群:Th1产生致炎性细胞因子,主要是IFN-γ,通过活化信号转导和转录因子(signal transducer and activator of transcription,STAT)-4及T-bet(Tbox expressed in Tcells)而发育,可增强对病毒或胞内病原体作出的细胞免疫反应;Th2细胞产生IL-4、IL-5、IL-9及IL-13,通过激活STAT-6及GATA-binding protein(GATA)-3而发育,主要与过敏性反应及抗寄生虫感染相关,在体液免疫和抗寄生虫感染中起重要的作用。近年来人们发现IL-17的生成细胞与炎症相关,为CD4+T细胞的一个亚群,被定义为Th17细胞。其发育与功能不同于Th1和Th2细胞系,受多种细胞因子的调节。研究表明,Th17细胞反应的异常与很多自身免疫状态相关,在自身免疫性疾病和感染性疾病中发挥重要的调节作用。

CD4+ T cells are traditionally divided into two major pedigrees:Th1 cells produce interferon(IFN)-γ and their primary role is to protect against intracellular microbes.Th1 cells are developed via activation of signal transducer activator of transcription(STAT)-4 and T box expressed in T cells(T-bet),and can enhance the intracellular pathogens or viruses to the cellular immune response.Th2 cells produce IL-4,IL-5,IL-9,and IL-13 and they are developed via activation of STAT-6 and GATA-binding protein(GATA)-3....