冰片-β-环糊精包合物对磷酸川芎嗪在小鼠血浆及脑组织分布的影响

Effects of borneol-β-cyclodextrin inclusion complex on the plasma and brain concentrations of tetramethylpyrazine phosphate in mice

目的:考察冰片-β-环糊精包合物对磷酸川芎嗪在小鼠血浆及脑组织分布的影响。方法:将冰片-β-环糊精包合物与磷酸川芎嗪的混合物灌胃给予小鼠,用GC-FID法测定不同时间血浆及脑组织中磷酸川芎嗪的浓度,通过3P97程序计算药动学参数。结果:磷酸川芎嗪血药浓度-时间曲线及脑组织浓度-时间曲线均符合一级吸收二室模型,冰片-β-环糊精包合物没有改变磷酸川芎嗪的体内行为。但与冰片原料相比,冰片-β-环糊精包合物对磷酸川芎嗪在小鼠血浆和脑组织中的增加程度没有直接用冰片原料的作用强。结论:建议在含有冰片的复方制剂中最好使用冰片原料或将冰片制成其他剂型使用。

Aim:To study the effects of borneol-β-cyclodextrin inclusion complex on mice plasma and brain concentrations of tetramethylpyrazine phosphate.Methods:Tetramethylpyrazine phosphate plasma and brain concentrations in mice after oral administration of tetramethylpyrazine phosphate with borneol-β-cyclodextrin inclusion complex at selected intervals were determined by GC-FID.The pharmacokinetic parameters were estimated by the program 3P97.Results:Both tetramethylpyrazine phosphate plasma and brain concentration...