机械通气对老年慢性肺原性心脏病患者血清脑钠肽的影响

The effect of mechanical ventilation on plasma brain natriuretic peptide in patients with chronic pulmonay heart disease

目的:探讨慢性肺原性心脏病患者在急性发作期合并呼吸衰竭时,血浆脑钠肽血清水平变化及临床意义。方法:选择慢性肺原性心脏病急性加重期,并有机械通气治疗指证60例患者,用酶联免疫吸附法测定治疗前后血清脑钠肽的水平。并与健康人40例比较,分析脑钠肽与动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)及右室射血前期时间(RVPEP)/肺动脉血流加速时间(AT)的相关性。结果:肺心病患者急性加重期机械通气治疗前后脑钠肽均显著高于健康人(P<0.01);治疗前脑钠肽明显高于治疗后(P<0.01),机械通气治疗后脑钠肽水平降低,两者均与PaO2呈负相关(均P<0.01),与PaCO2呈正相关(P均<0.01)。结论:机械通气治疗能降低肺心病患者脑钠肽,脑钠肽水平能反映老年慢性肺原性心脏病患者病情的严重程度,短期应用机械通气,能降低血浆脑钠肽水平。

Objective:To study the effects on the change of plasma brain natriuretic peptide(BNP) levels in the patients with chronic pulmonary heart disease received mechanical ventilation.Methods:Plasma BNP levels were measured by ELISA(enzyme-linked immunosorbent assay) from 60 patients with chronic pulmonary heart disease in acute stage before and after mechanical ventilation and 40 healthy people in control, analyzing their relationship with artery PaO2, artery PaCO2 and RVPEP(right ventricular pre-ejection period...