多囊卵巢综合征患者瘦素、雄激素、胰岛素关系临床研究

A clinical study on the correlation among leptin,testosterone and insulin in women with PCOS

目的:通过研究多囊卵巢综合征(PCOS)患者血清瘦素(Leptin)、雄激素(T)、胰岛素(Ins)之间的关系,为临床辅助诊断及治疗提供理论依据。方法:选取PCOS患者55例为研究组,正常人群26例为对照组,均分成肥胖组与非肥胖组,同时PCOS患者随机分3组:A组服达英-35,B组达英-35+二甲双胍,C组曲谱瑞林,治疗3个月,均测定血清Leptin、T、Ins、黄体生成素(LH)、促卵泡素(FSH)水平,进行相关性分析。结果:血清Leptin、Ins、T、LH水平PCOS组均高于相当体重指数对照组;且Leptin水平在肥胖组高于非肥胖组,Ins水平在PCOS组内肥胖组高于非肥胖组;PCOS患者血清瘦素、雄激素、胰岛素间呈正相关性;达英-35治疗组T、Leptin下降;达英-35+二甲双胍组T、Leptin、Ins均下降;曲谱瑞林组T下降显著,Leptin有下降,Ins水平虽有所下降,但差异无统计学意义;组间比较曲谱瑞林组T水平下降最显著。结论:达英-35联合二甲双胍可降低患者血清雄激素、瘦素、胰岛素水平;对PCOS顽固性高雄激素及高瘦素者短期应用促性腺激素释放激素激动剂(GnRH-a)可能获得更好疗效。

Objective:To detect the correlation among Leptin, testosterone(T), and insulin(Ins) and to put forward theoretical supports to clinical subsidiary diagnosis and treatment for women with polycystic ovarian syndrome(PCOS).Methods:The subjects were 55 patients with PCOS and 26 normal control women, both of whom were classified into two groups:obesity group and non-obesity group.At the same time, the PCOS women were divided randomly into three groups:women in Group A were treated with Diane-35, in Group B with ...