人口腔扁平苔藓及口腔鳞癌组织中P16、Survivin蛋白的表达

Expression of P16 and Survivin protein in oral lichen planus and oral squamous cell carcinoma tissue

目的:探讨正常口腔黏膜组织、口腔扁平苔藓(OLP)、口腔鳞状细胞癌(OSCC)组织中P16、Survivin蛋白的表达情况及其临床意义。方法:采用免疫组化SP法检测26例正常口腔黏膜组织、40例糜烂型OLP组织及40例OSCC组织中P16、Survivin蛋白的表达情况,并分析其相关性。结果:正常口腔黏膜组织中P16蛋白阳性表达22例(84.6%),糜烂型OLP组织中P16蛋白阳性表达21例(52.5%),OSCC组织中P16蛋白阳性表达9例(22.5%),3组间比较差异有统计学意义(χ2=48.36,P<0.05)。正常口腔黏膜组织中Survivin蛋白阳性表达1例(3.9%),糜烂型OLP组织中Survivin蛋白阳性表达12例(30.0%),OSCC组织中Survivin蛋白阳性表达22例(55.0%),3组间比较差异有统计学意义(χ2=26.46,P<0.05)。结论:P16、Survivin蛋白在OSCC的发生发展中起重要作用。

Aim:To study the expression and clinical significance of P16 and Survivin protein in oral lichen planus(OLP) and oral squamous cell carcinoma(OSCC) tissue.Methods:Immunohistochemical technique SP was used to detect the expression of P16 and Survivin protein in 40 cases of OSCC,40 cases of OLP tissues and 26 cases of normal oral mucosa,and their clinical significance was also analyzed.Results: The results showed that P16 in 9 cases of OSCC tissues(22.5%),in 21 cases of OLP tissues(52.5%),and in 22 cases of n...