SYNTHESIS AND pH-SENSITIVE SELF-ASSEMBLY OF DENDRITIC POLY(AMIDOAMINE)-b-POLY(L-GLUTAMATE) BIOHYBRIDS

SYNTHESIS AND pH-SENSITIVE SELF-ASSEMBLY OF DENDRITIC POLY(AMIDOAMINE)-b-POLY(L-GLUTAMATE)BIOHYBRIDS

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摘要 Dendritic poly(amidoamine)-b-poly(L-glutamate)(PAMAM-b-PLG) biohybrids were synthesized by the ring-opening polymerization ofγ-benzyl-L-glutamate N-carboxyanhydride monomer,followed by the deprotection of benzyl groups on poly(benzyl-L-glutamate),and were characterized by ~1H-NMR,FT-IR and gel permeation chromatography.The self-assembly behavior of the PAMAM-b-PLG biohybrid was investigated by means of UV-Vis,dynamic light scattering (DLS),transmission electronic microscopy(TEM) and ~1H-NMR.UV-Vis analysis ... Dendritic poly(amidoamine)-b-poly(L-glutamate)(PAMAM-b-PLG) biohybrids were synthesized by the ring-opening polymerization ofγ-benzyl-L-glutamate N-carboxyanhydride monomer,followed by the deprotection of benzyl groups on poly(benzyl-L-glutamate),and were characterized by ~1H-NMR,FT-IR and gel permeation chromatography.The self-assembly behavior of the PAMAM-b-PLG biohybrid was investigated by means of UV-Vis,dynamic light scattering (DLS),transmission electronic microscopy(TEM) and ~1H-NMR.UV-Vis analysis ...

作者董常明

机构地区 Department of Polymer Science & Engineering

出处《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2009年第6期797-805,共9页 高分子科学（英文版）

基金 supported by the National Natural Science Foundation of China(No.20674050) Shanghai Leading Academic Discipline Project(No.B202)

关键词 Dendritic PAMAM-b-PLG pH-sensitive self-assembly Nanoparticles Drug/gene delivery Dendritic PAMAM-b-PLG pH-sensitive self-assembly Nanoparticles Drug/gene delivery

分类号 O631.3 [理学—高分子化学]

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参考文献11

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Chinese Journal of Polymer Science

2009年第6期

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SYNTHESIS AND pH-SENSITIVE SELF-ASSEMBLY OF DENDRITIC POLY(AMIDOAMINE)-b-POLY(L-GLUTAMATE) BIOHYBRIDS

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