糖化血红蛋白在应激状态下血糖增高患者诊断中的应用

Study on the clinical meaning of the detection of HbA1c in stress

目的:观察在应激状态下HbA1c水平测定是否均能判断住院患者任何阶段血糖升高的性质。方法:测定外伤、手术、感染应激患者疾病急性期和稳定期的空腹血糖(FPG)浓度及糖化血红蛋白(HbA1c)水平。结果:(1)应激稳定期,B2组(双高组)HbA1c水平与A组(血糖正常对照组)、与B1组(单高组)比较差异有统计学意义,B1组HbA1c水平与A组比较差异无统计学意义。B2组FPG浓度与HbA1c水平呈显著正相关,A组与B1组FPG浓度与HbA1c水平均无显著性相关;(2)B1组(单高组)连续3周HbA1c水平相关,相邻2周差异均无统计学意义,但第1周与第3周差异有统计学意义;(3)ROC曲线分析显示,HbA1c=6.05%时,ROC曲线下面积最大,为检出糖尿病或糖耐量异常诊断最佳切点,其灵敏度为100.0%,特异度为98.2%。结论:(1)HbA1c水平测定能够区分住院患者血糖升高原因是应激性高血糖还是新诊断的糖尿病;(2)HbA1c受短期应激性高血糖影响出现一定程度的波动,但波动不足以影响应激性高血糖和糖尿病性高血糖鉴别诊断,均在HbA1c水平最佳切点范围以内。

Objective:To observe whether the detection of HbA1c would judge the cause of hyperglycemia in stress hospitalized patients at any time.Methods:Data were collected from hospitalized patients with hyperglycemia in stress(such as trauma,operation and infection).HbA1c and fasting plasma glucose(FPG) levels were tested in both acute and stable stage of all patients.Results:(1)At the stable stage,the HbA1c concentration of group B2(double high group),compared with that of normal contrast group or that of group B1...