女性激素替代治疗、口服避孕药与女性肺癌关系的Meta分析

Meta-analysis of the effects on hormone replacement therapy and oral contraceptives associated with female lung cancer risk

目的探讨女性激素替代治疗(HRT)与口服避孕药(OCs)对女性肺癌的影响。方法搜索Medline等计算机数据库,系统收集相关文献。采用固定模型或随机效应模型(研究结果存在异质性)计算合并OR。结果纳入Meta分析的文献共12篇,其中3篇为队列研究,9篇为病例对照研究。Meta分析HRT与肺癌合并OR值为0.88(95%CI:0.77～1.01)。按是否吸烟进行分层分析,吸烟者与非吸烟者中HRT的合并OR值分别为0.76(95%CI:0.61～0.95)和0.78(95%CI:0.64～0.95)。口服避孕药与女性肺癌无统计学关联(OR=0.95;95%CI:0.83～1.20)。结论HRT可能降低女性肺癌发生的危险度,其结果还需要进一步深入研究来验证。

Objective To evaluate the effects of hormone replacement therapy(HRT)and oral contraceptives(OCs)on lung cancer risk in women.Methods We retrieved studies by systematically searching Medline and other computerized databases.Pooled odds ratios(OR)were appropriately derived from fixed-effects or,in the presence of heterogeneity,random-effects models.Results Twelve studies were identified including 3 cohort studies and 9 case-control studies.The OR value associated with HRT was 0.88(95%CI:0.77-1.01).Subgroup a...