氟西汀抑制大鼠肺动脉高压及对GATA-4蛋白的影响

Relationship between the Inhibitory Effect of Fluoxetine on Pulmonary Arterial Hypertension and GATA-4 Protein in Rats

目的研究氟西汀(Flu)对野百合碱(MCT)诱导的大鼠肺动脉高压(PAH)的抑制及其与GATA-4蛋白表达的关系。方法建立MCT诱导的慢性炎性PAH大鼠模型。用不同剂量的Flu给大鼠灌胃,检测PAH各项指标和肺组织GATA-4蛋白表达水平。结果MCT诱导的大鼠肺动脉压、右心指数、肺动脉血管壁厚度以及肺组织GATA-4蛋白表达均明显增加,Flu剂量依赖性地降低了以上各项指标。结论大鼠PAH的形成与GATA-4过度表达有关。选择性5-羟色胺再摄取抑制剂Flu可能通过抑制GATA-4蛋白的表达而抑制MCT诱导的大鼠PAH。

Objective To study the relationship between the inhibitory effect of fluoxetine(Flu)on monocrotaline(MCT)-induced pulmonary arterial hypertension(PAH)and GATA-4 protein in rats.Methods The rat model of monocrotaline-induced PAH was established.The rats were lavaged with different doses of fluoxetine.The variables of PAH and the expression of GATA-4 protein in lung tissue were determined.Results Monocrotaline caused increases in pulmonary arterial pressure,right ventricular index,vessel wall thickness of pul...