不同血压对大鼠永久性脑缺血后神经保护的研究

Study of Protective Mechanism of Induced Different Blood Pressure in Rats with Permanent Cerebral Ischemia

目的探讨不同的血压诱导方式对大鼠急性永久性脑缺血后神经保护作用的机制。方法雄性SD大鼠32只,随机分为4组,对照组(n=8)、早期诱导血压升高组(n=8)、诱导血压降低组(n=8)、晚期诱导血压升高组(n=8)。采用线拴法制备永久性脑缺血大鼠模型,分别在脑缺血3h后药物诱导血压升高、3h后诱导血压降低、18h后诱导血压升高。在缺血24h时观察大鼠的神经功能评分以及脑梗死体积情况。结果脑缺血24h时,早期血压升高组较对照组梗死体积明显减少(P<0.05),血压降低组梗死体积最大(P<0.05),晚期血压升高组梗死体积和对照组相比没有统计学意义(P>0.05)。早期血压升高组大鼠的神经功能评分明显改善(P<0.05)。结论升高血压明显比降低血压能够减少急性永久性脑缺血大鼠梗死体积,改善神经功能。早期诱导血压升高比晚期诱导血压升高更具有神经保护作用。

Objective To study the protective mechanism of different induced blood pressures for acute permanent cerebral ischemia in rats. Methods Thirty two adult Sprague-Dawley rats were randomly divided into four groups,that was the control group,the early induced hypertension group (3h),the induced hypotension group,and the late induced hypertension group (18h).The middle cerebral arteries were occluded with threads according to the modified method and permanent ischemic models of rats were made. The blood pressur...