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苯扎贝特对血栓性疾病危险因素的影响 被引量：7

Influence of Beazafibrate on Risk Factors of Thrombotic Diseases
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摘要 目的探讨苯扎贝特对载脂蛋白(a)[LP(a)],高纤维蛋白原(FIB)及胰岛素抵抗(IR)的影响。方法临床筛选单纯高脂血症患者50例,合并2型糖尿病(NIDDM)患者50例,随机分成4组,不合并(A组)和合并(B组)NIDDM各30例为治疗组,口服苯扎贝特;另不合并(C组)和合并(D组)NIDDM各20例为对照组,口服安慰剂,疗程12周。结果A、B组经治疗后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、LP(a)、空腹血糖(FBG)和FIB均有较明显下降、高密度脂蛋白胆固醇(HDL-C)升高,糖耐量、胰岛素抵抗改善,胰岛素敏感指数(AS指数)上升,延长PT、KPTT时间,而对照组无显著差别。结论苯扎贝特具有全面改善脂代谢紊乱的作用,同时还有改善胰岛素抵抗、降低LP(a)、FIB以及改善凝血纤溶功能。 Objective To study the effect of bezafibrate on the thrombotic risks such as factor-apoprotein (a),hyperfibrinogen,and insulin-resistance. Methods Fifty patients with isolated hyperlipemia and 50 patients with hyperlipemia and non-insulin-dependent diabetes mellitus (NIDDM) were selected and divided into four groups. Group A had 30 patients with isolated hyperlipemia and group B had 30 patients with hyperlipemia and NIDDM,they all been treated by oral bezafibrate. Group C had 20 patients with isolated hyper...
作者 张立娟
机构地区 上海交通大学附属第九人民医院周浦分院神经内科
出处 《神经病学与神经康复学杂志》 2009年第1期31-34,共4页 Journal of Neurology and Neurorehabilitation
关键词 苯扎贝特 载脂蛋白(a) 胰岛素抵抗 高纤维蛋白原 beazafibrate Lipoprotein （a） insulin-resistance hyperfibrinogen
分类号 R589.2 [医药卫生—内分泌]
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二级参考文献18

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共引文献211

同被引文献44

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神经病学与神经康复学杂志
2009年 第1期

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