慢性肝病患者血清Ⅳ型胶原、透明质酸含量及其临床意义

Study on level change of serum type - IV collagen and hyaluranate in chronic liver disease patients.

目的探讨慢性肝炎、肝硬化患者血清Ⅳ型胶原(type Ⅳ collagen,Ⅳ-C)、透明质酸(Hyaluranate,HA)含量及其临床意义。方法采用双抗体夹心固相酶免疫法检测96例慢性乙型肝炎、肝硬化患者血清Ⅳ-C、HA含量,同时检测20例正常人作为对照组。结果Ⅳ-C、HA含量与慢性肝炎程度呈正相关,中、重度慢性肝炎、肝硬化患者血清Ⅳ-C、HA含量明显增高,与正常对照及慢性肝炎轻度组相比,差异有显著性(P<0.05)。结论血清Ⅳ-C、HA检测可作为肝纤维化的诊断指标之一,联合检测可提高准确率。

Objective To study the level change of serum type - Ⅳ collagen (Ⅳ-C) and Hyaluranate (HA) in chronic hepatitis and h'ver cirrhosis patients and their value in diagnosis of liver cirrhosis. Method solid phase - sandwich - enzyme immunoassay was used to recorder the level of Ⅳ -C and HA in 96 chronic HBV hepatitis and liver cirrhosis patients and compared with 20 normal people. Result The serum level of HA and Ⅳ-C was correlated with the degree of hepatic fibrosis. Compared with normal people and mild chronic hepatitis, the level of serum Ⅳ -C and HA in moderate and severe chronic hepatitis and h'ver cirrhosis patients significandy raised (P<0.05) .Conclusion The level of serum Ⅳ-C and HA can be used as important diagnostic index in evaluation of the degree of hepatic fibrosis. When they used together, the diagnostic accuracy raised.