妊娠期高血压疾病患者血清瘦素和肿瘤坏死因子α的变化

Studies on the Levels of Leptin and TNF - α in Patients with Hypertension Disorder Complicating Pregnancy

目的探讨外周血清瘦素和肿瘤坏死因子-a(TNF-α)在妊娠期高血压疾病(HDCP)发病中的作用。方法分别采用放免法测定61例HDCP患者与20例健康晚孕妇女(对照组)血清瘦素和TNF-α水平。结果①轻度、重度子痫前期组血清瘦素和TNF-α水平较对照组显著升高(P<0.01);②HDCP组血清瘦素和TNF-α水平之间呈显著直线正相关(P<0. 01)。结论瘦素和TNF-α在妊娠期高血压疾病的病理生理过程中发挥重要的生理作用,动态监测瘦素和TNF-α水平对预测其病情、指导临床治疗有重要意义。

Objective To evaluate the roles of leptin and TNF - α in pathophysiological changes of Hypertension Disorder Complicating Pregnancy ( HDCP). Methods Levels of sera leptin and Tumor necrosis factor - α (TNF - α) in 20 normal late preg-nant women and 61 patients with HDCP were measured by radioimmunoassay. Results ①Levels of sera leptin and TNF - a in HDCP group were significantly higher than those of normal tenn pregnant women. ②Positive correlation was observed between leptin and TNF -α in HDCP group ( p <0. 01). Conclusion leptin and TNF -α may play important roles in the pathogenesis of HDCP. TO detect leptin and TNF -α continuously has important value in prognosis and treatment of HDCP.