α-干扰素、病毒唑及更昔洛韦治疗小儿手足口病

Comparison The Ganciclovir L alpha-interferon and Virazole in treatment of hand-feet-mouth disease in Children

目的探讨α-干扰素、更昔洛韦与病毒唑治疗小儿手足口病的临床疗效。方法将120例手足口病患儿随机分为三组,分别给予干扰素组、更昔洛韦组、病毒唑组各40例。三组均计退热时间及手、足、口腔疱疹结痴时间及并发症,同时观察药物的毒副作用。结果更昔洛韦组平均退热时间及疱疹结痴时间,明显少于干扰素组及病毒唑组。三组药物治疗过程中无明显毒副作用。更昔洛韦组并发症明显少于干扰素组。结论更昔洛韦治疗小儿手足口病明显优于干扰素和病毒唑。

Objective To explore the curative effects of ganciclovir, alpha-interferon and virazole on hand-feet-mouth disease. Methods One hundred twenty children with hand-feet-mouth disease were divided in three groups treated with gancidovir , alpha-interferon and virazole respectively. The time of fever relieving and scabbing of the patients from three groups was observed separately. Results The time of fever relieving and the time of scabbing in gancidovir group was shorter than of the alpha-interferon group and virazole group;The side effect of three groups was not serious .Conclusion Gancidovir is more effective than alpha-interferon and virazole in the treat ment of hand-feet-mouth diseas.