东莞地区健康学龄前儿童肺炎链球菌和流感嗜血杆菌携带株耐药性研究

Study on drug susceptibility of streptococcus pneumoniae and haemophilus influenzae from children of Dongguan city

目的了解东莞地区学龄前健康儿童鼻咽部携带肺炎链球菌和流感嗜血杆菌状况以及部分分离株对常用抗生素的耐药情况。方法选择四家幼儿园共344名学龄前健康儿童取鼻咽双份标本培养,分离鉴定肺炎链球菌和流感嗜血杆菌菌,并做药敏试验。结果肺炎链球菌和流感嗜血杆菌携带率分别是38.37%和18.3%。各取50株进行药敏实验,肺炎链球菌对大多数抗生素均有不同程度耐药,青霉素耐药株(PRSP)为14.6%,中敏株(PISP)为29.2%,敏感株(PSSP)为56.2%,不敏感株(PNSSP)为43.8%。红霉素和四环素耐药率达70%以上。流感嗜血杆菌产β酰胺酶株占8%;对氨苄西林不敏感率为8%。结论东莞地区学龄前健康儿童鼻咽部肺炎链球菌和流感嗜血杆菌携带率高于国内一些地区,耐药和多重耐药现象严重。

Objective To study of the status and streptococcus pneumoniae and haemophilus influenzae isolated from rhinopharynx of healthy children in Dongguan city and the drug resistance of part separated strains.Methods 344 healthy children from 4 kindergartens were studied. And the streptococcus pneumoniae and haemophilius influenzae isolated from the children were detection of drug resistance to antibiotics.Results The detection rate of streptococcus pneumoniae and haemophilus influenzae was 38.37% and 18.3% respectively. 50 strains of them were examined for antibiotics resistance test. Streptococcus pneumoniae had different resistant to most of antibiotics. PRSP, PISP ,PSSP and PNSSP was 14.6%, 29.2%, 56.2%and 43.8% respectively。The resistant rate or TE and E was over 70%。Haemophilus influenzae of beta-lactamase producing was 8% and the rate of resistance to AM was 8%。Conclusion The detection rate of streptococcus pneumoniae and haemophilius influenzae was higher than that of other cities of China ,and the resistance and multiple resistant drug were serious.