895例成人幽门螺杆菌感染状况分析

Analysis on the Helicobacter pylori Infection and its Relative Factors among 895 Adults

目的了解成人幽门螺杆菌(Hp)感染状态,探讨成人Hp感染状况及其与相关因素的关系。方法采用ELISA方法对全部病例进行血清抗Hp-IgG检测,同时取胃窦、胃体粘膜2块分别作病理组织学检查和快速尿素酶检查找Hp,3种方法中两项或两项以上阳性者诊断为Hp感染。结果总感染率为42.23%,农村为51.94%,城市为32.89%,农村高于城市(P<0.01);按年龄分组的感染率18～、30～、45～、60～75岁者分别为20.81%、32.21%、48.18%、57.02%,随着年龄的增长,感染率增加(P<0.01);Hp感染率存在职业差别,农民、医务人员感染率较高,分别为54.75%和41.67%,从事文化教育、行政管理人员感染率较低分别为24.22%和29.23%(P<0.01);无症状组成人Hp感染率(31.02%)明显低于有症状组的感染率(51.42%,P<0.01)。结论Hp在成人中感染率较高,与城乡分布、年龄、职业有关,与症状学密切,应进一步加强幽门螺杆菌的防治工作。

Objective To investigate the status of helicobacter pylori(Hp) infection among adults, and to study the relationship between theHp infection and its relative factors. Methods 895 cases were studied on their serum Hp-IgG using ELISA, and for Hp with rapid ureasetest and histological examination. Hp infection was diagnosed by at least two criteria. Results The total Hp infection rate was found to be42.23%. Rates in the rural and urban areas were 51.94% and 32.89% respectively. The total infection rate of rural areas was higher than thatof urban areas(P<0.01).The total Hp infection rates among adults of 18-,30-,45-,60-years old were 20.81%、32.21%、48.18% and 57.02%respectively, with an increase with ageing(P<0.01). The rate of Hp infection shows significant differences in professions. The total infection ratesof peasant (54.75%) and medical professionals (41.67%)were in general higher than those of the teachers (24.22%)and managers (29.23%)(P<0.01).The rate of Hp infection in asymptomatic adults(31.02%) was significantly lower than that in patients with gastrointestinal symptoms (51.42%) (P<0.01). Conclusions The rate of Hp infection among adults was high and became a common disease, which was related to ageing,profession and residential areas. There was a close association between the symptomatology and the rate of Hp infection. Prevention and treatmentof Hp infection in adults should be strengthened.