21-氨基类固醇U-74389G对脑外伤后记忆功能的影响

A Study of the Neuroprotection Effect of 21－Aminosteroid U－74389G post Traumatic Brain Injury

目的探讨21－氨基类固醇U－74389G对脑外伤后脑保护作用。方法用记忆功能测定箱，对中度脑损伤大鼠不同时期的记忆功能进行测试评分，并进行脑组织病理检查。结果伤前及伤后早期给药能显著提高脑损伤大鼠的记忆功能水平，减轻神经病理损害。结论U－74389G对大鼠脑外伤后记忆功能有保护作用。

Objective The study was designed to evaluate the protect effect of 21－Aminosteroid (U－74389G) on experiment Traumatic Brain Injury (TBI).Methods The memory test was made by memorying test task before and during different period after TBI,then the brain tissure histology was examined.Results The rat which U－74389G was administrated before or immediately after TBI got higher cognitive memory scores than contral group and the neuropathalogical damage was ameliorate.Conclusion U－74389G has protective effect on TBI.